Thrilled to share that Brown University and OncoOne have published key aspects of oxMIF biology in Redox Biology. Our most recent paper, “Redox-dependent plasticity of oxMIF facilitates its interaction with CD74 and therapeutic antibodies,” explores how MIF, undergoes oxidation to oxMIF by neutrophil-released myeloperoxidase (MPO). This oxidation enhances oxMIF’s flexibility and binding to its receptor, CD74, which native MIF cannot do.

These findings, revealed through NMR, mass spectrometry, ELISA, SPR, and cell-based assays, highlight the structural changes in oxMIF that promote its interaction with CD74, offering a promising route for therapeutic intervention. This proves once again that structural changes influenced by environmental conditions are an important regulatory mechanism and the high potential of OncoOne’s portfolio targeting oxMIF.

Please follow the link to access the article: https://doi.org/10.1016/j.redox.2024.103264

Congratulations to first author Sara Sajko and thanks to George Lisi and his amazing team at Brown University for their invaluable contributions!